From Milan by car:
Take the motorway A9, which connect Milan to Switzerland, direction Como-Chiasso till Como Nord (last exit for Italy). Take the SS 340 Statale Regina and follow the road signs in direction of Menaggio and drive along it for 20 km, passing by Argegno, Colonno and Sala Comacina until the bell tower of Ossuccio on your right. Then, follow the instructions on the printed map to reach the Residence Letizia.
There is a Ferrovie Nord train connection from the airport directly to the Como centre

From Switzerland-Chiasso by car:
CHIASSO
Take the motorway A2, which reaches frontier with Italy at Chiasso and becomes then A9, direction Milan-Como. Out of Chiasso,take direction Como nord, then follow the Statale Regina SS 340 and follow the road signs for Menaggio and drive along it for 20 km, passing by Argegno, Colonno and Sala Comacina until the bell tower of Ossuccio on your right.
Then, follow the instructions on the printed map to reach the Residence Letizia.

Gandria-Swiss Frontier by car:
From the centre of the City of Lugano, follow for Gandria-Oria taking the Road to Gandria, direction Porlezza. From Porlezza, follow the Strada Statale 340 direction Menaggio. Once at Menaggio, stay on the SS 340 and follow direction Como and drive along it for about 6 km passing by Griante-Cadenabbia, Tremezzo, Azzano-Mezzegra, Lenno until you reach the bell tower of Ossuccio on your left.
Then, follow the instructions on the printed map to reach the Residence Letizia.

By Train:
Como San Giovanni is an international train station served by Ferrovie dello stato and where you can easily get either C 10 bus service to Ossuccio or Taxi. There is a Ferrovie Nord train connection from the airport directly to the Como centre, Stazione Lago from where you can take either the SPT bus service (C10) to Ossuccio or get a taxi.

Milan Malpensa – International and intercontinental flights:
Malpensa Express connects Malpensa International Airport to the centre of Milan Cadorna Station served by Ferrovie Nord.
The following link provides more information :
http://www.malpensaexpress.it/ing/index.html